Najwa Ejje, Ernest Lacey and Rachel Codd
RSC Advances 2012, 2, 333-337
Publication Date: October 12, 2011
The potent histone deacetylase inhibitor trichostatin A (TSA) has been captured in a single step with high selectivity from the culture supernatant of the native TSA-producing strain Streptomyces hygroscopicusMST-AS5346 using analytical-scale Ni(II)-based immobilised metal affinity chromatography.
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