Onnamide F:  A New Nematocide from a Southern Australian Marine Sponge, Trachycladus laevispirulifer

Dat Vuong, Robert J. Capon, Ernest Lacey, Jennifer H. Gill, Kirstin Heiland, and Thomas Friedel

Journal of Natural Products, 2001, 64, 640-642.

Publication Date: April 26, 2001



A southern Australian marine sponge, Trachycladus laevispirulifer, has yielded a potent new nematocide with antifungal activity which has been identified as onnamide F (1). The structure for 1 was assigned by detailed spectroscopic analysis and chemical conversion to the methyl ester 2. Onnamide F contains a common structural motif previously described in a number of natural products exhibiting interesting pharmacological activities, including the insect chemical defense agent pederin (3), and the sponge metabolites the onnamides, mycalamides, and theopederins.

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