Robert J. Capon, Colin Skene, Edward Hsiang-Te Liu, Ernest Lacey, Jennifer H. Gill, Kirstin Heiland, and Thomas Friedel
Journal of Organic Chemistry, 2001, 66, 7765-7769.
Publication Date: October 2, 2001
https://doi.org/10.1021/jo0106750
Abstract:
Bioassay-directed fractionation of the EtOH extract of an Oceanapia sp. collected off the northern Rottnest Shelf, Australia, has yielded three novel dithiocyanates, thiocyanatins A (1), B (2a), and C (2b). The structures were determined by detailed spectroscopic analysis and confirmed by total synthesis. In addition to featuring an unprecedented dithiocyanate functionality, thiocyanatins possess an unusual 1,16-difunctionalized n-hexadecane carbon skeleton and are revealed as a hitherto unknown class of nematocidal agent.
