Synthesis of 4-phenylthieno [2, 3-c] quinolines via Suzuki-Miyaura cross-couplings

Hyland, Isabel K. ; Ho, Curtis C. ; Vuong, Daniel ; Tsai, Yi An ; Lacey, Ernest ; Bissember, Alex C. ; Smith, Jason A.; Koutentis, Panayiotis A.

ARKIVOC free online journal of organic chemistry, 2022-09, Vol.2022 (4), p.110-122

Publication Date: August 16, 2022



A small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple
thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions. These heterocycles were screened for activity against various bacterial, fungal, parasitic
and cancer cell lines, which identified two original 4-(2-methoxyphenyl)-thieno[3,2-c]quinolines that display
encouraging antibacterial activity.

Contact Us

Business Development

Microbial Diversity

Metabolic & Chemical Diversity




Stay in the loop

Recent publications