Albanitriles A-G: antiprotozoal polyacetylene nitriles from a mycale marine sponge.

Samuele Sala, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey, and Gavin R. Flematti

J. Nat. Prod. 2019, 82, 3450-3455.

Publication Date: December 13, 2019


Seven new nitrile-bearing polyacetylenes, named albanitriles A–G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.

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