Hang Li, Cameron L. M. Gilchrist, Heather J. Lacey, Andrew Crombie, Daniel Vuong, John I. Pitt, Ernest Lacey, Yit-Heng Chooi, and Andrew M. Piggott
Org. Lett., 2019, 1287-1291.
Publication Date: February 8, 2019
https://doi.org/10.1021/acs.orglett.8b04042
Abstract:
The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.
