Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi

Hang Li, Paul M. Mirzayans, Mark S. Butler, Alastair E. Lacey, Daniel Vuong, Rachel Chen, John A. Kalaitzis, Stephen A. Moggach, Ernest Lacey, Andrew M. Piggott and Yit-Heng Chooi

Chemical Communications 2022, 58 (43), 6296-6299

Publication Date: May 4, 2022

https://doi.org/10.1039/D2CC01679F

Abstract:

The brevijanazines are novel p-nitrobenzoylated piperazines isolated from Aspergillus brevijanus. Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and in vitro microsomal assays unveiled the biosynthetic pathway to the brevijanazines, featuring a cytochrome P450 oxygenase that converts p-aminobenzoic acid to p-nitrobenzoic acid.

Contact Us

Business Development

Microbial Diversity

Metabolic & Chemical Diversity

Technology

Publications

BioAustalis

Stay in the loop

Recent publications

View all publications

Fungal Duel between Penicillium brasilianum and Aspergillus nomius Results in Dual Induction of Miktospiromide A and Kitrinomycin A

Michael S. Cowled, John A. Kalaitzis, Andrew Crombie, Rachel Chen, Nicolau Sbaraini, Ernest Lacey, and Andrew M. Piggott J. Nat. Prod. 2023, 86, 10, 2398–2406 Publication Date: September 22, 2023 https://doi.org/10.1021/acs.jnatprod.3c00593 Abstract: Cocultivation of...

Drug susceptibility testing for oxygen-dependent and oxygen-independent resistance phenotypes in trichomonads

Alexander Y.F. Lam, Ernest Lacey, Vesna De Petra, Deborah A Williamson, Jan Šlapeta, Aaron R. Jex, Samantha J. Emery-Corbin Publication Date: November 26, 2022 https://doi.org/10.1016/j.ijpara.2022.11.010 Abstract: Trichomonas vaginalis is the most prevalent,...

Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp.

Rachel Chen, Scott A. Minns, John A. Kalaitzis, Mark S. Butler, Maira Rosin, Daniel Vuong, Soo Sum Lean, Yit-Heng Chooi, Ernest Lacey, and Andrew M. Piggott J. Nat. Prod. 2023, 86, 8, 2054–2058 Publication Date: August 1, 2023...