Esmodil: An Acetylcholine Mimetic Resurfaces in a Southern Australian Marine Sponge Raspailia (Raspailia) SP

Robert J. Capon,Colin Skene,Edward H. Liu,Ernest Lacey,Jennifer H. Gill,Kirstin Heiland & Thomas Friedel

Natural Product Research, 18: 305-309.

Publication Date: August 19, 2003


Bioassay directed fractionation of a Raspailia (Raspailia) sp. (Order Poecilosclerida; Family Raspailiidae) collected during scientific trawling operations off the Northern Rottnest Shelf yielded as nematocidal agents the known metabolites, phorboxazoles A (1) and B (2). Further examination revealed the new natural product but known synthetic compound, esmodil (3). The structure for 3 was confirmed by spectroscopic analysis and total synthesis.

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