Ranjala Ratnayake, Ernest Lacey, Shaun Tennant, Jennifer H. Gill, and Robert J. Capon
Organic Letter, 2006, 8, 5267-5270.
Publication Date: October 20, 2006
https://doi.org/10.1021/ol062113e
Abstract:
The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion. A proposed biosynthesis requires a novel molecular twist that generates an unprecedented heterocyclic system and differentiates the isokibdelones from their kibdelone co-metabolites. SAR analysis on the isokibdelones further defines the anticancer pharmacophore of these novel polyketides.
