Rugulotrosins A and B:  Two New Antibacterial Metabolites from an Australian Isolate of a Penicillium sp.

Michael Stewart, Robert J. Capon, Jonathan M. White, Ernest Lacey, Shaun Tennant, Jennifer H. Gill, and Martin P. Shaddock

Journal of Natural Products, 67: 728-730.

Publication Date: March 3, 2004


Two new antibacterial agents, rugulotrosin A (1) and B (2), were obtained from cultures of a Penicillium sp. isolated from soil samples acquired near Sussex Inlet, New South Wales, Australia. Rugulotrosin A (1) is a chiral symmetric dimer, and its relative stereostructure was determined by spectroscopic and X-ray crystallographic analysis. Rugulotrosin B (2) is a chiral asymmetric dimer isomeric with 1. Its structure was determined by spectroscopic analysis with comparison to the co-metabolite 1 and previously reported fungal metabolites. Both rugulotrosins A and B displayed significant antibacterial activity against Bacillus subtilis, while rugulotrosin A was also strongly active against Enterococcus faecalis and B. cereus.

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