Hyland, Isabel K. ; Ho, Curtis C. ; Vuong, Daniel ; Tsai, Yi An ; Lacey, Ernest ; Bissember, Alex C. ; Smith, Jason A.; Koutentis, Panayiotis A.
ARKIVOC free online journal of organic chemistry, 2022-09, Vol.2022 (4), p.110-122
Publication Date: August 16, 2022
10.24820/ark.5550190.p011.813
Abstract:
A small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple
thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions. These heterocycles were screened for activity against various bacterial, fungal, parasitic
and cancer cell lines, which identified two original 4-(2-methoxyphenyl)-thieno[3,2-c]quinolines that display
encouraging antibacterial activity.
